 |
|
|
|||||||||||||||
 |
|||||||||||||||||
|
|||||||||||||||||
|
|
|
 |
||
|
Vitamin E Chinoy NJ, Sharma A - “Amelioration of fluoride toxicity by vitamins E and D in reproductive functions of male mice” Fluoride 31(4):203-216 (1998) Shah SD, Chinoya NJ - “Adverse effects of fluoride and/or arsenic on the cerebral hemisphere of mice and recovery by some antidotes" Fluoride 37(3):162-171 (2004) “SUMMARY: The effects of oral administration of sodium fluoride (NaF) and/or arsenic trioxide (As2O3) at 5 and 0.5 mg/kg body weight doses, respectively, for 30 days were studied on the physiology and histology of brain (cerebral hemisphere) of adult mice (Mus musculus). Recovery after 30 additional days by some antidotes (vitamins C and E and calcium phosphate) was also examined. The observed significant decline in levels of DNA and RNA and acetylcholinesterase activity in brain (cerebral hemisphere) of mice treated with NaF, As2O3 and NaF + As2O3 is related to its altered histology. The combined antidote treatment was conducive for recovery of this fluoride and arsenic induced toxicity in the brain. These results are viewed as having important implications for fluoride and arsenic endemic populations all over the globe.” Compare with the effects of Viamin E on cadmium toxicity (cadmium can produce the same mottled enamel as observed in dental fluorosis!). See Cadmium Gupta P, Kar A - "Cadmium induced thyroid dysfunction in chicken: hepatic type I iodothyronine 5'-monodeiodinase activity and role of lipid peroxidation" Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 123(1):39-44 (1999) http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10390054&dopt=Ab stract Tazhibaev ShS, Mamyrbaev AA, Takhtaev FKh - "Phospholipid composition of membrane lipids of hepatic subcellular structures in rats under the effects of different nutrition and phosphorus and fluorine “The enrichment of the diet with retinol, tocopherol, ascorbic acid and thiamine reduced the membrane-damaging action of hydrogen fluoride and phosphine.” Tazhibaev ShS, Mamyrbaev AA, Takhtaev FKh - "Effect of the combined action of hydrogen fluoride and phosphine on the structural and functional properties of the sarcoplasmic reticulum membranes of the myocardium with nutrition of varying character" Vopr Pitan 1(5):40-3 (1985) Thyroid Status & Vitamin E Brzezinska-Slebodzinska E - "Fever induced oxidative stress: the effect on thyroid status and the 5'-monodeiodinase activity, protective role of selenium and vitamin E" J Physiol Pharmacol 52(2):275-84 (2001) Chaurasia SS, Kar A - “Protective effects of vitamin E against lead-induced deterioration of membrane associated type-I iodothyronine 5'-monodeiodinase (5'D-I) activity in male mice” Toxicology 124(3):203-9 (1997) Danis IuK, Marchiulenite DIu, Danite EIu, Cherniauskene RCh - “Vitamin E and malondialdehyde in the blood serum of thyrotoxicosis patients” Probl Endokrinol (Mosk) 36(5):21-4 (1990) “The concentrations of vitamin E and malonic dialdehyde (MDA) were investigated in the blood serum of 146 patients with diffuse goiter of various degree of severity and in 35 controls with diffuse and nodular goiter without thyroid dysfunction. Vitamin E and MDA concentrations in patients with mild thyrotoxicosis did not differ from that in the controls. Vitamin E concentrations in patients with moderate and severe types of thyrotoxicosis were notably decreased and MDA concentration was elevated. The data on decreased vitamin E concentrations and increased MDA concentrations indicated vitamin E insufficiency in these patients. This fat-soluble antioxidant is recommended for multimodality therapy of thyrotoxicosis.” Krishnamurthy S, Prasanna D - “Serum vitamin E and lipid peroxides in malnutrition, hyper and hypothyroidism” Acta Vitaminol Enzymol. 6(1):17-21 (1984) Mutaku JF, Many MC, Colin I, Denef JF, van den Hove MF - "Antigoitrogenic effect of combined supplementation with dl-alpha-tocopherol, ascorbic acid and beta-carotene and of dl-alpha-tocopherol alone in the rat" J Endocrinol 156(3):551-61 (1998) (Admin of E has an anti-goitrogenic effect during iodine deficiency, no effect of Vit c, or beta-carotene; Vit E levels in thyroid as high as in liver in normal rats; levels higher than in plasma;decreases during iodine deficiency in the liver, while it increases in thyroid and plasma;alpha tocopherol content in liver exceeds that in other tissues ; cocktail slowed down goiter development; no change on TSH or thyroid hormones...surprisingly in control admin of cocktail and Vit E alone increased thyroid weight; w/ slight decrease in T4 levels by cocktail; “Vit E was the only component that reproduced its antigoitrogenic effect while Vitamin C or beta-carotene increased goiter weight...”) Mutaku JF, Poma JF, Many MC, Denef JF, van Den Hove MF - "Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced involution" J Endocrinol 172(2):375-86 (2002). Sarandol E, Tas S, Dirican M, Serdar Z - “Oxidative stress and serum paraoxonase activity in experimental hypothyroidism:effect of vitamin E supplementation.” Cell Biochem Funct (2004) Shinohara R, Mano T, Nagasaka A, Hayashi R, Uchimura K, Nakano I, Watanabe F, Tsugawa T, Makino M, Kakizawa H, Nagata M, Iwase K, Ishizuki Y, Itoh M - “Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status” J Endocrinol. 164(1):97-102 (2000) “Concentrations of alpha-tocopherol in the old rats were high in the hyperthyroid state and low in the hypothyroid state.” Venditti P, De Leo T, Di Meo S - “Vitamin E administration attenuates the tri-iodothyronine-induced modification of heart electrical activity in the rat” J Exp Biol 200 ( Pt 5):909-14 (1997) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list _uids=9100363 |
||