Vitamin A
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see also: VITAMIN A
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Harris SS, Navia JM - "Interaction of vitamin A deficiency and excess fluoride in calcification of rat bones and teeth" Acta Vitaminol Enzymol 6(3):201-9 (1984)

"Using a 2 X 2 factorial design, we evaluated the possible interaction of vitamin A deficiency and excess fluoride in rat dentin and bone. Simultaneous presence of excess fluoride plus vitamin A deficiency resulted in a significant decrease in bone fluoride concentration compared to the presence of excess fluoride alone. Vitamin A deficiency alone significantly reduced calcium concentration in dentin formed during the deficient period."

Lucas PA, Ophaug RH, Singer L - "The effect of vitamin A deficiency and fluoride on glycosaminoglycan metabolism in bone" Connect Tissue Res 13(1):17-26 (1984)

"The effects of fluoride intake and vitamin A deficiency on glycosaminoglycan metabolism in vivo were investigated. Weanling female rats were fed either a vitamin A deficient diet ad libitum, a vitamin A supplemented diet pair-fed to the deficient animals, or the vitamin A supplemented diet ad libitum. Additionally, each vitamin A dietary group was divided into three subgroups with the animals receiving water containing 0, 10 or 50 ppm fluoride. The results showed that the groups receiving 10 and 50 ppm fluoride at all dietary levels of vitamin A had significantly higher in vivo 35SO4 incorporation in both the epiphyseal and diaphyseal regions of the bone than the animals receiving 0 ppm fluoride. The vitamin A deficient animals incorporated significantly less 35SO4 into glycosaminoglycans in the epiphyseal and diaphyseal regions of the bone compared to the pair-fed, vitamin A sufficient animals for all three fluoride receiving groups. There was no interaction between fluoride intake and dietary vitamin A levels on 35SO4 incorporation into glycosaminoglycans. Fluoride either increased sulfation or turnover of glycosaminoglycans."

Nockels CF, Ewing DL, Phetteplace H, Ritacco KA, Mero KN - "Hypothyroidism: an early sign of vitamin A deficiency in chickens" J Nutr 114(9):1733-6 (1984)

"These results indicate that one of the earliest signs of vitamin A deficiency in chicks is hypothyroidism."

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Dabon-Almirante CL, Damle S, Wadler S, Hupart K - "Related case report: in vivo suppression of thyrotropin by 9-cis retinoic acid" Cancer J Sci Am 5(3):171-3 (1999)

Takegawa K, Mitsumori K, Onodera H, Mutai M, Kitaura K, Takahashi M, Uneyama C, Yasuhara K, Takahashi M, Yanai T, Masegi T, Hayashi Y - "UDP-GT involvement in the enhancement of cell proliferation in thyroid follicular cell proliferative lesions in rats treated with thiourea and vitamin A" Arch Toxicol 71(11):661-7 (1997)

Breen JJ, Hickok NJ, Gurr JA - "The rat TSHbeta gene contains distinct response elements for regulation by retinoids and thyroid hormone" Mol Cell Endocrinol 131(2):137-46 (1997)