Calcium/Magnesium
© 1996 - 2004 PFPC

Fluoride-Magnesium Interaction
by A. Machoy-Mokrzynska

The Question of Fluoridation
by J. R. Marier

Coming Soon: Thyroid hormones control calcium metabolism.

Wu HW, Wen JX, Qu GR - “Changes in fluorine metabolism during the treatment with calcium-magnesium preparation in 60 cases of endemic fluorosis” Chung Hua Nei Ko Tsa Chih 29(6):357-9, 383 (1990)

• Using the method of metabolic balance, we investigated the fluoride metabolism and its change during calcium-magnesium preparation treatment in 60 cases of endemic fluorosis. We found that in patients with fluorosis the intake of fluoride and the levels of urinary, fecal and serum fluoride were several times higher than those of normal controls (P less than 0.01), that the intestinal fluoride apparent absorption rate was 1.5 times higher than that of normal controls (P less than 0.01) and that at a given dietary level of fluoride, there existed a balance of fluoride metabolism. Fluoride intake was positively correlated with intestinal fluoride apparent absorption rate (r = 0.375, P less than 0.01). The combination of calcium and magnesium preparation with fluoride led to decrease of intestinal fluoride apparent rate (P less than 0.05) and increase of fecal fluoride output (P less than 0.05). It seems reasonable to treat fluorosis with calcium-magnesium preparation.

McClure FJ, Mitchell HH -
"The effect of fluorine on the calcium metabolism of albino rats and the composition of bones"
J Biol Chem 90: 297 - 320 (1931)

Thyroid Status & Magnesium

Dolev E, Deuster PA, Solomon B, Trostmann UH, Wartofsky L, Burman KD - “Alterations in magnesium and zinc metabolism in thyroid disease” Metabolism 37(1):61-7 (1988)

“Magnesium (Mg) and zinc (Zn) status was assessed in subjects to evaluate the effects of thyroid diseases on Mg and Zn metabolism. Plasma and red blood cell (RBC) concentration and peripheral blood mononuclear cell (MNC) content of Mg and Zn, and 24-hour urinary excretion of Mg, Zn, creatinine (Cr), calcium (Ca), sodium (Na), and potassium (K) were measured in 11 thyrotoxic, 29 hypothyroid, and 25 euthyroid control subjects. Serum albumin, alpha 2-macroglobulin, and the binding of Zn to albumin were also determined. Plasma and RBC Mg concentrations were low in half of the hyperthyroid subjects, but mean values were not significantly different from controls. Urinary excretion and clearance of Mg were lower in hypothyroid subjects, but differences were removed when expressed relative to Cr excretion and clearance. Similar patterns were noted for urinary Ca, Na, and K, suggesting that their reduced excretion reflects alterations in renal hemodynamics. Plasma Zn was lower in hypothyroid subjects and correlated with serum albumin; MNC Zn and urinary Zn were also low. Plasma Zn concentration was normal and serum albumin significantly lower in the hyperthyroid group than in the control group. Further, RBC Zn content was significantly lower in hyperthyroid subjects, and inversely related to plasma thyroxine concentration. The hyperthyroid group also excreted significantly greater amounts of Zn than controls, indicative of a catabolic process. This increased urinary loss may reflect a shift in the distribution of plasma Zn between ultrafilterable and Zn-albumin complexes. In summary, this study provides evidence for marked alterations in Zn homeostasis in persons with thyroid disease. Whether the observations indicate deficiency states and have clinical implications will require further investigation.”

Wang SP, Li P, Qiu HX - “Disorder of magnesium metabolism in hyper- and hypothyroid patients” Zhonghua Nei Ke Za Zhi 24(2):98-101, 126 (1985)

Thyroid & Calcium

SEE ALSO:
Fluoride & Vitamin D
Thyroid & Vitamin D

Verrotti A, Greco R, Altobelli E, Morgese G, Chiarelli F - "Bone metabolism in children with congenital hypothyroidism--a  longitudinal study" J Pediatr Endocrinol Metab 11(6):699-705  (1998)                      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9829 223

“Before the beginning of therapy, the hypothyroid patients showed higher values of calcium (2.78 +/- 0.04 vs 2.65 +/- 0.07 mmol/l; p < 0.05) and of 1,25-dihydroxy-vitamin D (159.7 +/- 31.6 vs 90.5+/- 33.1 ng/l; p < 0.01”