PFPC
Bone

Fluoride = TSH 
Effects on Bone

 

TSH

Fluoride

TSH causes a concentration-dependent inhibition of osteoclast formation (Abe et al, 2003)

Fluoride causes a concentration-dependent inhibition of osteoclast formation

TSH  modulates resorption and formation independently. (Abe et al, 2003)

Fluoride modulates resorption and formation independently

Increases c-jun expression (Abe et al, 2003)

Increases c-jun expression
(Zhang et al, 2005; Misra et al, 2002))

TSHR Attenuates Osteoclastogenesis by Inhibiting JNK/c-jun and NFκB Signaling (Abe et al, 2003)

 

Translocation of p65 (and not of p50) was inhibited selectively in response to TSH

 

 

 

 

 

 

 

 

 

References:

Cao X, Kambe F, Seo H - "Requirement of thyrotropin-dependent complex formation of protein kinase A
catalytic subunit with inhibitor of {kappa}B proteins for activation of p65 nuclear factor-{kappa}B by tumor necrosis factor-{alpha}" Endocrinology 146(4):1999-2005 (2005)

Chen L, Tong A, Yu D, Chen R - "Effects of fluoride on the expression of c-fos and c-jun genes and cell proliferation of rat osteoblasts" Zhonghua Yu Fang Yi Xue Za Zhi 34(6):327-9 (2000)

Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, Bianco AC – “Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation” Endocrinology 146(1):195-200 (2005)

Kikumori T, Kambe F, Nagaya T, Funahashi H, Seo H - "Thyrotropin modifies activation of nuclear factor kappaB by tumour necrosis factor alpha in rat thyroid cell line" Biochem J 354(Pt 3):573-9 (2001)

Misra UK, Gawdi G, Pizzo SV - "Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation" J Leukoc Biol 71(3):487-94 (2002)

Morimura T, Tsunekawa K, Kasahara T, Seki K, Ogiwara T, Mori M, Murakami M – “Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin” Endocrinology 146(4):2077-84 (2005)

Pomerance M, Abdullah HB, Kamerji S, Correze C, Blondeau JP - "Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species" J Biol Chem 275(51):40539-46 (2000)

Sun YM, Yang FJ, Li YM, Lu B, Zhu M, Qiu MC - “Expression of Fas, FasL, and NF-kappa B in the process of osteoclast-like cell apoptosis effected by sodium fluoride” Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24(5):491-4 (2002)

Wijayanti N, Kietzmann T, Immenschuh S - "Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes" J Biol Chem 280(23):21820-9 (2005)

Zhang WL, Cui YN, Gao S, Zhang XY, Li GS - "Expression of proto-oncogenes c-fos and c-jun in osteoblasts activated by excessive fluoride" Zhonghua Yu Fang Yi Xue Za Zhi 37(4):246-50 (2003)

 


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