The possibility that either dental fluorosis (Chapter 4) or the delayed tooth eruption noted with high fluoride intake (Chapter 4;
see also Short 1944) may be attributable at least in part to an effect of fluoride on thyroid function has not been studied. (NRC 2006, page 198)
This statement is entirely untrue. This issue has been studied for many decades since the early 1900’s (Schuld, 2005; McKay, 1918;
Wilson & De Eds,1940; De Eds, 1940; Steyn, 1964; etc.). The Review itself cites numerous studies which have found clear evidence that fluoride and thyroid hormones have "mutually interacting
effects" on 'dental fluorosis' (i.e Zhao et al, 1998; Yang et al, 1994; Lin et al, 1991).
See also comment: Delayed Eruption
DeEds F, Wilson RH, Cutting WC - "Thyrotropic hormone and fluorine activity"
Endocrinology 26(6):1053-1056 (1940)
Lin Fa-Fu, Aihaiti, Zhao Hong-Xin, Lin Jin, Jiang Ji-Yong, Maimaiti, and Aiken - "The Relationship of a Low-Iodine and High-Fluoride Environment to Subclinical Cretinism in Xinjiang" Endem Dis Bull (6)62-68 (1991)
McKay, FS - "Progress of the year in the investigation of mottled enamel with special
reference to its association with artesian water" J Natl Dental
Assn 5:721 (1918)
Schuld A - "Is Dental Fluorosis Caused By Thyroid Hormone Disturbances?
Fluoride 38(2)91-94 (2005)
Steyn DG - "Once More - Fluoridation" Review. University of Pretoria NUWE REEKS No.24 (1964)
Wilson RH, DeEds F - "The Synergistic Action Of Thyroid On Fluoride
Toxicity" Endocrinology 26:851 (1940)
Yang Y, Wang X, Guo X - "Effects of high iodine and high fluorine on children's intelligence and the metabolism of iodine and fluorine"
Chinese Journal of Epidemiology 15(5):296-8 (1994)
Zhao WY - "A preliminary study of the interaction of iodide and fluoride in experimental iodide-goiter and fluorosis" Chinese Preventive Medicine 22:146-148 9 (1988)
Zhao W, Zhu H, Yu Z, Aoki K, Misumi J, Zhang X - "Long-term Effects of Various Iodine and Fluorine Doses on the Thyroid and Fluorosis in Mice"
Endocr Regul 32(2):63-70 (1998)